Animal Use in Science: Exploring the 3Rs

Module 3

Replacement: Alternatives to Using Animal Models in Testing, Research, and Education

Competency: Outline various ways to replace the use of animals in research

Learning objectives:

  • Identify why researchers may try to replace the use of animals in their research
  • Describe examples of human simulators, cell-based models, and humane dissection tools as methods of replacement
  • Describe the common issues associated with traditional drug development methods and how replacement technology can address those issues
  • Provide research-backed support for the effectiveness of replacement

Assessment: Classroom Animal Use Alternatives Proposal

  • Proposal identifies the educational activity and types of animals that will be replaced
  • Proposal identifies how many animals are used in the current activity
  • Proposal identifies specific examples of products/activities animals could be replaced with
  • Proposal identifies drawbacks of using animals in your classroom
  • Proposal identifies cost considerations for the solution
  • Proposal identifies safety and/or reliability considerations for the solution
  • Proposal identifies social and/or cultural considerations for the solution
  • Proposal identifies environmental impact of the solution
Download Materials

Lesson plan, worksheets, and activities (PDF, 1.1 MB)


Public Opinion Polls on Animal Testing
(PowerPoint, 12.0 MB)

(PowerPoint, 35.1 MB

Linked External Standards:


HS-ESS3-4 Evaluate or refine a technological solution that reduces impacts of human activities on natural systems

HS-ETS1-3 Evaluate a solution to a complex real-world problem based on prioritized criteria and trade-offs that account for a range of constraints, including cost, safety, reliability, and aesthetics as well as possible social, cultural, and environmental impacts.

Common Core State Standards - ELA

RST.11-12.7 Integrate and evaluate multiple sources of information presented in diverse formats and media (e.g., quantitative data, video, multimedia) in order to address a question or solve a problem.

RST.11-12.9 Synthesize information from a range of sources (e.g., texts, experiments, simulations) into a coherent understanding of a process, phenomenon, or concept, resolving conflicting information when possible.

W.9-10.1 Write arguments to support claims in an analysis of substantive topics or texts, using valid reasoning and relevant and sufficient evidence.